This special issue brings together different national and scholarly perspectives to analyze the potential of the Quad Plus from varied national and regional connotations. The volume considers whether the Quad Plus framework can emerge as a central focus of the emerging Indo-Pacific synergies or approaches of various regions and nation states. Accordingly, the special issue is divided into three parts. The first, “Beijing, Quad, and the Quad Plus,” discusses the grouping from the viewpoints of the core Quad 2.0 states—the United States, India, Japan, and Australia, beginning with a special article on the Chinese perspective on the Quad process. The second part, titled “The ‘Plus’ Perspectives,” seeks to consider the prospects that the grouping holds for middle powers and previously included parties such as the Association of Southeast Asian Nations, United Kingdom, South Korea, Israel, France, Canada, and Brazil. The third and last section expands the scope to discuss perspectives of countries like Russia, the Indian Ocean island states, the Middle East, Pakistan–Afghanistan–Iran, and of course, with a focus on history and politics that the region delves upon pertaining to connectivity and infrastructure. Together, these articles aim to discuss not only the present approaches of the nations/regions in question toward the Quad Plus but also assess how their policies may evolve in the future amid a more hotly contested Indo-Pacific region and an intensifying US–China rivalry. (Note: An updated version of this issue will post in early 2021.)