The unfolding military confrontation between Israel and Iran introduces significant geopolitical risk to the commercial realization of the India-Middle East-Europe Economic Corridor (IMEC). Earlier in 2023, some of the anticipated challenges for the IMEC corridor were evident, namely the paramount need for security and stability in the Middle East, which hasn’t been the case. As the Israel-Iran conflict deepens following Israel’s multi-pronged air operation “Rising Lion” against Iran’s nuclear infrastructure, regional security dynamics have entered a new phase of volatility. This new outlook not only threatens maritime and land-based supply chains amid Iran’s retaliation, but also emerging strategic partnerships—particularly the India–UAE segment of IMEC. For regional policymakers and security officials, the moment calls for a sober reassessment of IMEC’s rollout pace, security safeguards, and diplomatic frameworks.